& Russo-Menna, I
Because its considered off-label, theres little clinical evidence to show whether this kind of do-it-yourself dosing is actually effective, or just anecdotal
That makes it effective even in patients with reduced insulin production, and it carries a low risk of hypoglycemia when used alone
In branched amino acid catabolism, the branched-chain -ketoacid dehydrogenase complex requires TPP to convert branched-chain -ketoacids into branched-chain acyl-CoA, which is then converted into acetyl-CoA and enters the citric acid cycle
The good news is that longer treatment duration also means your body has had more time at a lower weight, which may establish a lower metabolic set point
If you have been working hard on your weight and metabolic health and feel like your body is not cooperating, you are not alone, and it is not about willpower